动物肿瘤模型是临床前研究中验证靶点功能和抗体疗效的关键工具。这一过程包括多个步骤：选择合适的模型（如异种移植小鼠）、通过基因调控验证靶点、测试抗体、优化给药方案、探索联合治疗策略、分析生物标志物、进行影像学研究、评估免疫反应和毒性。全面的方法为抗体疗法的潜在疗效和安全性提供了至关重要的数据支持。
Animal tumor models are critical tools in preclinical research for validating target function and antibody efficacy. This process involves multiple steps: selecting appropriate models (such as xenograft mice), validating targets through genetic regulation, testing antibodies, optimizing dosing regimens, exploring combination therapy strategies, analyzing biomarkers, conducting imaging studies, and evaluating immune responses and toxicity.
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将体外培养的人源细胞移植到小鼠皮下。优势包括：实验周期短，成功率高。小鼠疾病机制与人类相似，增强研究的临床相关性。
Transplants cultured human tumor cells into mice subcutaneously. Benefits include standardized transplantation, brief experimental cycles, and high success rates.
将患者的肿瘤组织直接移植到小鼠体内，保留了原始肿瘤的异质性。这种方法用于在更贴近临床的环境中研究肿瘤生物学并评估抗癌治疗的效果。
PDX models transplant patient tumor tissue into mice, maintaining original tumor heterogeneity. This method enables evaluations in a setting that closely mimics clinical conditions.
通过将肿瘤细胞注射到小鼠体内的特定位置，诱导原发肿瘤生长，并随后向其他部位转移。该模型对研究癌症转移机制和开发针对转移过程的治疗策略至关重要。
This model facilitates the study of tumor progression and metastasis by introducing cancer cells into specific locations in mice. It plays a crucial role in elucidating metastatic mechanisms and advancing targeted therapeutic interventions.
另有组织病理切片、组织染色、免疫染色、非肿瘤动物疾病模型，敬请垂询。
We also offer histopathological sections, tissue staining, immunostaining, non-tumor animal disease models and large animal models. Please inquire for more details.
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