GPCRs 是对细胞信号传导至关重要的多样化膜蛋白。这些受体以七个跨膜结构域为特征，能够响应外部刺激并触发细胞内级联反应。作为超过30%的FDA批准药物的靶点，GPCRs在生物医学研究、疾病理解和药物开发中发挥着重要作用。
GPCRs are diverse membrane proteins crucial for cellular signaling. These receptors, characterized by seven transmembrane domains, respond to external stimuli and trigger intracellular cascades. Their study is essential for advancing scientific knowledge and personalized medicine.
Get StartedG蛋白偶联受体（GPCRs）因其独特性质而在表达和纯化过程中面临诸多挑战。它们的疏水特性、离开膜环境后的不稳定性、低表达水平，以及特定的翻译后修饰需求，都使生产过程变得复杂。此外，过度表达可能对宿主细胞造成毒性。这些因素导致获取用于研究和药物发现的功能性GPCRs变得困难，需要采用专门的膜蛋白生产技术。
GPCRs pose unique challenges in expression and purification due to their hydrophobic nature, instability, low yields, and specific modification requirements. Overexpression can be toxic to host cells. These factors necessitate specialized production techniques for obtaining functional GPCRs for research and drug discovery.
我们的GPCR表达和纯化服务克服了与膜蛋白相关的挑战。我们提供优化的表达系统、定制的去垢剂筛选、脂质纳米盘技术、尖端的纯化方法。
Our GPCR expression and purification service employs advanced techniques to overcome the challenges associated with membrane proteins. We offer optimized expression systems, custom detergent screening, lipid nanodisc technology, cutting-edge purification methods, and rigorous quality control measures.
测量下游G蛋白活性的功能测定对于理解受体功能和评估潜在药物候选物至关重要。这些测定为GPCR功能性、配体效能和可能的非特异性效应提供了关键洞见。通过提供一系列这些方法，我们的服务促进了对GPCR信号传导的全面表征，支持基础研究和药物发现计划。
GPCR functional assays measuring downstream G protein activity are essential for understanding receptor function and evaluating potential drug candidates. By providing a range of functional assays, we support both fundamental research and drug discovery initiatives.
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我们的冷冻电子显微镜（cryo-EM）技术使我们能够在接近天然状态下观察这些复杂的膜蛋白，为基础科学研究和药物开发提供了至关重要的结构信息。
Our cryo-electron microscopy (cryo-EM) services allows visualization of these complex membrane proteins in their near-native state, providing crucial information for both basic research and drug discovery.
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