Mass Spectrometry and Proteomics Analysis (基于蛋白质普的蛋白组学研究): Unraveling the Protein Universe

质谱(MS)是一种强大的分析技术,它彻底革新了蛋白质组学,使研究人员能以前所未有的精确度和灵敏度识别、定量和表征蛋白质。该方法通过将分子离子化,根据离子的质荷比分离这些离子,并检测它们来生成质谱图。蛋白质组学需要高度依赖质谱技术来揭示细胞蛋白质表达和功能的复杂全貌。

Mass spectrometry (MS) is a powerful analytical technique that has revolutionized proteomics, allowing researchers to identify, quantify, and characterize proteins with unprecedented accuracy and sensitivity. This method works by ionizing molecules, separating these ions based on their mass-to-charge ratio, and detecting them to generate a mass spectrum. Proteomics—the large-scale study of proteins—heavily relies on mass spectrometry to unravel the complex landscape of cellular protein expression and function.

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Featured Technical Services
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de novo Protein Sequencing
蛋白从头测序

从头蛋白质测序是一种先进的分析技术,无需依赖先前的序列信息或基因组数据库即可确定蛋白质的氨基酸序列。特别适用于研究新型蛋白质、未测序基因组的生物体或具有翻译后修饰的蛋白质。

De novo protein sequencing has numerous applications in biotechnology, pharmaceutical research, and proteomics studies. It is particularly useful in discovering new bioactive peptides, characterizing recombinant proteins, and studying proteins from non-model organisms.

Four-dimensional Proteomics
4D 蛋白质组学

4D蛋白质组学在传统3D蛋白质组学(基于保留时间、质荷比和离子强度)的基础上,增加了第四个维度—离子淌度。在理解复杂的生物系统、发育过程和疾病的分子基础方面特别有价值。

4D proteomics adds a fourth dimension—ion mobility—to traditional 3D proteomics (based on retention time, mass-to-charge ratio, and ion intensity). It is particularly valuable in understanding complex biological systems, developmental processes, and the molecular basis of diseases.

Applications 应用场景

Circulating Markers
血液蛋白标志物

对血液高丰度的蛋白标志物进行氨基酸测序。提供精确的蛋白靶点序列信息。

Examine high-abundance protein biomarkers in blood samples and provides precise sequence information for targeted proteins.

Antibody Sequencing 抗体测序

对单克隆抗体、多克隆抗体/ 单域纳米抗体进行全覆盖测序。确保准确的CDR序列。

Perform full-coverage sequencing of monoclonal antibodies, polyclonal antibodies, and single-domain nanobodies. Ensure accurate amino acid sequences of CDR regions.

Neo-antigen Discovery 新抗原鉴定

精确鉴定主要组织相容性复合体(MHC)在细胞表面呈递蛋白质片段。

Precise identification of protein fragments presented on the cell surface by the major histocompatibility complex (MHC).

Proteomics
蛋白组学

4D蛋白质组学改善了对于标准液相色谱和质谱难以有效分析的复杂样品的蛋白质组学。

4D proteomics improves clinical proteomic analysis of complex samples that are challenging for standard liquid chromatography & mass spectrometry.

Mass Spectrometers Selection 质谱选择

我们平台可以满足绝大部分前沿蛋白发现与鉴定需求。技术人员会为您的项目匹配最合适的质谱。您亦可以按照您的经验选择。我们能提供以下质谱或液相色谱-质谱联用技术服务

Our platform meets the majority of cutting-edge protein discovery and identification needs. Our expert technical staff will match the most suitable mass spectrometer to your project, or you can choose based on your own experience. We offer a range of mass spectrometry and liquid chromatography-mass spectrometry coupling technologies to serve your research needs.

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