骆驼科动物和鲨鱼的纳米抗体拥有相似的特性，包括单域结构、小体积和高稳定性。延长的CDR3区域能够识别隐藏的抗原表位。这些独特的特点使纳米抗体在研究、诊断和治疗领域具有显著优势，相较于传统抗体更具价值。
Camelid and shark nanobodies share properties like single-domain structure, small size, and stability. Their extended CDR3 regions access hidden epitopes. These features make nanobodies valuable in research, diagnostics, and therapeutics, offering advantages over conventional antibodies.
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由于体积小，纳米抗体能够进入常规抗体难以到达的组织和抗原表位。
纳米抗体的简单结构通常导致较低的免疫原性，可能减少临床应用中的副作用。
纳米抗体在各种条件下能保持其结构和功能，允许更灵活的给药途径和配方。
单域特性有利于基因操作和与其他分子的融合，使得创造新型治疗药物成为可能。
纳米抗体的小体积导致其在体内更快清除，有利抗体显影医疗成像应用。
利用中国药典收录的表面等离子共振技术 (SPR) 技术，实时记录纳米抗体与抗原的结合和解离过程。挑选高亲和力纳米抗体作为候选药物。
SPR technology enables real-time monitoring of nanobody-antigen interactions. High-affinity nanobodies are then selected as potential antibody drug candidates.
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利用合适的动物疾病模型，验证和评估纳米抗体的体内疗效
Utilize appropriate animal disease models to validate and evaluate the in vivo efficacy of nanobodies.
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利用原子级别解析度的冷冻电子显微镜，结构抗体抗原结构。通过抗体结合位点和构像变化，解析抗体作用机制。为后续专利注册和抗体人源化开发提供实在的科学依据。
Employ cryo-electron microscopy to elucidate antibody-antigen structures with atomic precision. Analyze binding sites and conformational changes to gain insights into antibody mechanisms. This comprehensive structural information provides a solid scientific foundation for patent applications and facilitates the antibody humanization process.
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